Under is an approximation of this video’s audio content material. To see any graphs, charts, graphics, pictures, and quotes to which Dr. Greger could also be referring, watch the above video.
In a landmark case that made all of it the way in which as much as the U.S. Courtroom of Appeals earlier than being denied evaluate by the Supreme Courtroom, POM Fantastic (the pomegranate juice firm) vs. Federal Commerce Fee, a panel of judges concluded that lots of POM’s advertisements made deceptive or false claims touting medical research ostensibly displaying that pomegranate merchandise might assist deal with varied illnesses, together with coronary heart illness, prostate most cancers, and erectile dysfunction, and the First Modification doesn’t shield misleading and deceptive ads. Putting a blow to its billionaire homeowners, the Courtroom dominated that at the least one randomized scientific trial might be required to substantiate any claims of treating or stopping illness.
If you happen to take a look at the medical literature on the advantages of pomegranates basically, you’ll see opinions like this, with diagrams like this on the “medicinal results of pomegranate.” However if you happen to dig slightly deeper, you see that is primarily based on research like this: “antiobesity results of pomegranate leaf extract in a mouse mannequin.” To begin with, who eats pomegranate leaves? And second of all, who’s a mouse? And if you happen to do have a fats pet mouse, possibly simply feed them much less lard.
Does pomegranate consumption have an effect on weight in people? If you happen to take a look at all of the randomized managed scientific trials (which means human trials), pomegranates haven’t any vital impact on physique weight, BMI, stomach fats, and even physique fats share in these randomized to pomegranate product consumption. What about for the prevention and remedy of cardiovascular illnesses? Researchers reviewed 25 scientific trials, ldl cholesterol, blood strain, artery operate, atherosclerotic plaque formation, and platelet operate, and…even in the very best research, they didn’t discover vital indications of profit.
Right here’s a examine on pomegranate juice and erectile dysfunction. It was funded by the POM firm, and but it failed as nicely. No profit for diabetes markers, and no profit for persistent obstructive pulmonary illnesses, like emphysema. They had been banking on the antioxidant exercise of pomegranate juice to assist, however that’s antioxidant exercise in vitro (which means in a check tube or petri dish).
To my shock, a meta-analysis of information from 11 randomized managed trials did not assist convincing proof of pomegranate consumption having a major rising impact on complete antioxidant capability of your bloodstream, as a result of a few of the most potent antioxidants don’t even appear to be absorbed into the human physique. No marvel pomegranate supplementation didn’t appear to have an effect on oxidative stress in tissue samples taken from prostate most cancers sufferers. However, in fact, what we care about is whether or not it impacts the most cancers Itself.
The strongest proof for the anticancer exercise of pomegranates is alleged to return from research on prostate most cancers. Sadly, early promising outcomes weren’t conﬁrmed once they had been truly put to the check. For instance, day by day pomegranate Consumption was present in a randomized managed trial to haven’t any influence on PSA ranges, a marker of tumor development. And, certainly, a randomized, double-blind, placebo-controlled trial discovered primarily no distinction when it got here to prostate most cancers illness development.
They had been banking on the anti-inflammatory exercise of pomegranate juice to assist, however once more, that had been demonstrated in vitro. In individuals, a meta-analysis primarily based on 5 randomized managed trials printed in 2016 concluded that pomegranate juice didn’t have a major impact on C-reactive protein ranges, a key marker of irritation. If you happen to take a look at the forest plot, although, you’ll see all 5 trials tended in the direction of decrease C-reactive protein ranges such that the information mixed nearly reached statistical significance. And certainly, an up to date meta-analysis printed in 2020 primarily based on seven research did certainly get tipped over into significance, and located a major drop in two different inflammatory markers as nicely.
Huh, okay. Effectively, possibly pomegranate juice might assist in the management of inﬂammatory illnesses in any case. However you don’t know, till you place it to the check.
Osteoarthritis entails the degeneration of the cushioning cartilage inside joints, significantly the knees. If you happen to take some human osteoarthritic cartilage samples and drip on a pomegranate extract, you’ll be able to present cartilage-protective results. Right here’s how a lot cartilage disintegration was occurring at baseline. Add some irritation, and cartilage breakdown triples, however then add increasingly of this pomegranate extract, and you’ll calm issues down. However once more, that’s in a petri dish. How do we all know that once we eat pomegranates, the lively parts truly get into our bloodstream to allow them to discover their manner into our joints? Cartilage-protecting parts had been discovered to be bioavailable (at the least in rabbits), elevating the chance that pomegranates might be a protected and unhazardous remedy with no negative effects––versus the medication at present in use. However is it efficient?
Medical trials are in progress, and so many questions might be answered…proper now! The primary and solely scientific trial so far on pomegranate juice and osteoarthritis. It’s not a placebo-controlled trial, however as a substitute randomized individuals to pomegranate juice or nothing in any respect. These consuming the juice did report much less stiffness and impairment of bodily operate, however not considerably higher than simply doing nothing. Shoot.
However simply as I used to be about to surrender on pomegranates, I noticed this examine: Consumption of a pomegranate extract suppresses joint injury in rheumatoid arthritis. However no, it was simply the POM ‘Not-So-Fantastic’ firm inducing joint injury in a mouse as a mannequin of rheumatoid arthritis. Come on!
What about this open-labeled examine, the place the sufferers knew what they had been getting? Eight individuals with lively rheumatoid arthritis took some pomegranate extract every single day, and the six who caught with it reported fewer tender joints. However as we discovered from the osteoarthritis examine, if you happen to don’t have a management group you don’t have any sense of what function, if any, the remedy truly performs.
And so lastly, we come to this: a randomized, double-blind, placebo-controlled trial. It’s about time! Half of the themes unknowingly received some pomegranate extracts; the opposite half unknowingly received the equal of a sugar tablet and…vital enchancment within the variety of swollen joints, tender joints, ache depth, a illness exercise rating, a well being evaluation questionnaire, and morning stiffness, in comparison with placebo. So, when you have rheumatoid arthritis, I’d certainly suggest you begin consuming pomegranates. Why not simply pop pomegranate tablets? In spite of everything, it was a pomegranate extract that alleviated illness exercise. One good purpose to stay to the fruit is that when 19 pomegranate dietary supplements had been truly examined in a laboratory, most didn’t truly seem to have any pomegranate in them in any respect! Solely 6 out of 19 gave the impression to be genuine.
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